Directed evolution of novel AAV variants using the MCMS library for enhanced CNS tropism and reduced liver targeting in mice

Directed evolution of novel AAV variants using the MCMS library for enhanced CNS tropism and reduced liver targeting in mice

Systemic delivery of adeno-associated virus serotype 9 (AAV9) to the central nervous system (CNS) is insufficient due to hindrance from the tight junctions of the blood-brain barrier (BBB). While peptide-display-based AAV engineering has advanced CNS-targeting capsid development, traditional strateg...

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Bibliographic Details
Main Authors: Qingkai Song, Jiamei Wu, Qingfeng Zhang, Shufang Wu, Xin Luo, Mengmeng Xu, Yinxia Xu, Gang Wang, Hang Yu, Hui Chen, Zhike Lu, Lijia Ma
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
AAV
directed evolution
CNS
blood-brain barrier
MCMS library
capsid variant
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050125001172
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