Comparison of methods of optimal cut-point selection for biomarkers in diagnostic medicine: a simulation study with application of clinical data in health informatics

Abstract Objectives Several methods of cut-point selection for biomarkers have been suggested in biomedical research but the superiority of them over others was not studied comprehensively under different pairs of distributions, degree of overlap, and the ratio of sample sizes. This simulation study...

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Bibliographic Details
Main Authors: Mojtaba Hassanzad, Karimollah Hajian-Tilaki, Zinatossadat Bouzari, Shahla Yazdani
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Research Notes
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Online Access:https://doi.org/10.1186/s13104-025-07245-9
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