Chlamydia trachomatis modulates the expression of JAK-STAT signaling components to attenuate the type II interferon response of epithelial cells

Chlamydia trachomatis modulates the expression of JAK-STAT signaling components to attenuate the type II interferon response of epithelial cells

ABSTRACT Chlamydia trachomatis has adapted to subvert signaling in epithelial cells to ensure successful intracellular development. Interferon-γ (IFNγ) produced by recruited lymphocytes signals through the JAK/STAT pathway to restrict chlamydial growth in the genital tract. However, during Chlamydia...

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Bibliographic Details
Main Authors: Francis L. Fontanilla, Joyce A. Ibana, Rey A. Carabeo, Amanda J. Brinkworth
Format: Article
Language:English
Published: American Society for Microbiology 2024-10-01
Series:mBio
Subjects:
intracellular pathogen
JAK-STAT
interferon
immune evasion
Chlamydia
Online Access:https://journals.asm.org/doi/10.1128/mbio.01834-24
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https://journals.asm.org/doi/10.1128/mbio.01834-24

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