The kinase domain of TRPM7 interacts with PAK1 and regulates pancreatic cancer cell epithelial-to-mesenchymal transition

Abstract Pancreatic ductal adenocarcinoma (PDAC) is the main and the deadliest form of pancreatic cancer. This is a major problem of public health since it will become the second leading cause of death by cancer in the next few years, mainly due to the lack of efficient therapies. Transient Receptor...

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Main Authors: Julie Auwercx, Bernadette Neve, Alison Vanlaeys, Mathilde Fourgeaud, Ingrid Bourrin-Reynard, Mouloud Souidi, Sylvie Brassart-Pasco, Frédéric Hague, Stéphanie Guenin, Belinda Duchene, Laurent Gutierrez, Olivier Destaing, Isabelle Dhennin-Duthille, Isabelle Van Seuningen, Nicolas Jonckheere, Mathieu Gautier
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07665-2
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