Inhibitory Effects of 3-(4-Hydroxy-3-methoxyphenyl) Propionic Acid on Amyloid β-Peptide Aggregation In Vitro

Inhibitory Effects of 3-(4-Hydroxy-3-methoxyphenyl) Propionic Acid on Amyloid β-Peptide Aggregation In Vitro

<b>Objectives</b>: The compound 3-(4-Hydroxy-3-methoxyphenyl) propionic acid (HMPA) is a terminal metabolite derived from polyphenol compounds. It has been studied for its potential to support brain health indirectly through its anti-oxidant effects and ability to enhance the gut environ...

Full description

Saved in:

Bibliographic Details
Main Authors:	Makoto Mori, Hiroto Nakano, Sadao Hikishima, Jota Minamikawa, Daiki Muramatsu, Yasuhiro Sakashita, Tokuhei Ikeda, Moeko Noguchi-Shinohara, Kenjiro Ono
Format:	Article
Language:	English
Published:	MDPI AG 2025-07-01
Series:	Biomedicines
Subjects:	3-(4-hydroxy-3-methoxyphenyl) propionic acid amyloid β-protein aggregation nucleation mature fibril Aβ seeds
Online Access:	https://www.mdpi.com/2227-9059/13/7/1649
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Synthesis of β‐Alanine From Isoleucine and Propionate Catabolism via Aminotransferases
by: Margo H. Goldfarb, et al.
Published: (2024-12-01)

Methods of synthesis of 1,2,4-triazole derivatives with methoxyphenyl and study the spectrum of their pharmacological activity
by: D. V. Dovbnia, et al.
Published: (2023-04-01)

Bis[(2-methoxyphenyl)diphenylphosphane-κP](nitrito-κ2O,O′)silver(I)
by: Frederick P. Malan, et al.
Published: (2025-03-01)

Indole-3-propionic acid enhances growth performance and reduces diarrhea via modulating redox status and intestinal inflammation in weaned piglets
by: Dongxu Ming, et al.
Published: (2024-12-01)

Indole-3-propionic acid promotes hepatic stellate cells inactivation
by: Mariana Ilha, et al.
Published: (2025-03-01)

International society of sports nutrition position stand: β-hydroxy-β-methylbutyrate (HMB)
by: John A. Rathmacher, et al.
Published: (2025-12-01)

Quercetin ameliorates obesity and inflammation via microbial metabolite indole-3-propionic acid in high fat diet-induced obese mice
by: Jiaxin Lu, et al.
Published: (2025-04-01)

Indole-3-propionic acid promotes Schwann cell proliferation following peripheral nerve injury by activating the PI3K/AKT pathway
by: Huimei Zhang, et al.
Published: (2025-07-01)

Effects of oral supplementation of β -hydroxy-β -methylbutyrate on muscle mass and strength in individuals over the age of 50: a meta-analysis
by: Nan Li, et al.
Published: (2025-04-01)

Baitouweng decoction modulates gut microbial production of indole-3-propionic acid and epithelial necroptosis to alleviate DSS-induced colitis in mice
by: Jingyi Hu, et al.
Published: (2025-07-01)

Enhanced growth and productivity of useful metabolites by indole-3-propionic acid treatment in Lemna aequinoctialis culture
by: Ye-Been Lee, et al.
Published: (2025-08-01)

Exploring the effects of resveratrol and β-hydroxy-β-methylbutyric acid under different protein levels on the ileal health of tibetan sheep
by: Wei Gao, et al.
Published: (2025-07-01)

Biochemical and embryocidal side effects of indole-3-propionic acid and indole-3-butyric acid on albino mice (Mus musculus var. albus)
by: Ahmed S. Abdel-Aty, et al.
Published: (2025-06-01)

Anti-Inflammatory Potential of 3-Hydroxy-β-Ionone from <i>Moringa oleifera:</i> Decreased Transendothelial Migration of Monocytes Through an Inflamed Human Endothelial Cell Monolayer by Inhibiting the IκB-α/NF-κB Signaling Pathway
by: Thitiya Luetragoon, et al.
Published: (2024-12-01)

Dataset on the ketonisation of pure propionic acid and its mixture with pyrolysis bio-oil over metal oxide catalysts into 3-pentanone a biofuel precursorMendeley Data
by: Jude A. Onwudili, et al.
Published: (2025-08-01)

Determination of the shelf life of the API morpholinium 2-((4-(2-methoxyphenyl)-5-(4-pyridyl)-4H-1,2,4-triazol-3-yl)thio)acetate
by: A. H. Kaplaushenko, et al.
Published: (2025-07-01)

Propionate reinforces epithelial identity and reduces aggressiveness of lung carcinoma
by: Vignesh Ramesh, et al.
Published: (2023-09-01)

Transcriptomic and metabolomic insights into the synergistic effects of resveratrol and β-hydroxy-β-methylbutyric acid on hepatic function under varying protein diets in Tibetan sheep
by: Yu Zhang, et al.
Published: (2025-07-01)

Resveratrol and β-hydroxy-β-methylbutyric acid supplementation promotes ileal development and digestive function by altering microbial community abundance and metabolites in Tibetan sheep
by: Jiacheng Gan, et al.
Published: (2024-12-01)

ROLE OF GSK-3 IN Wnt/β-CATENIN SIGNALING PATHWAY IN OBESITY
by: A. S. Kulakova, et al.
Published: (2021-10-01)

Localization of TGF-β3 in intra bony defect treated by local application of chitosan \ β- TCP in rabbits
by: Zainab AJ Almashhadi, et al.
Published: (2025-06-01)

Corrigendum: α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor density underlies intraregional and interregional functional centrality
by: Taisuke Yatomi, et al.
Published: (2024-12-01)

The influence of resveratrol and β-Hydroxy-β-methyl butyric acid supplementation alone or in combination on the development and health of the duodenum in Tibetan sheep
by: Yu Zhang, et al.
Published: (2025-07-01)

Physiological Benefits, Applications, and Future Directions of β-Hydroxy-β-Methylbutyrate (HMB) in Food and Health Industries
by: Sijing Zhou, et al.
Published: (2025-04-01)

Identification of biomarkers related to propionate metabolism in schizophrenia
by: Weiqi Xie, et al.
Published: (2025-04-01)

DEVELOPMENT AND VALIDATION OF BIOANALYTICAL METHOD FOR QUANTIFICATION OF PINOLINE AND ITS METABOLITE 6-OH-1,2,3,4-TETRAHYDROCARBOLINE FOR THE PURPOSE OF CYPD26 ACTIVITY DETERMINATION
by: R. K. Abdrashitov, et al.
Published: (2019-01-01)

Design and Development of D-A-D Organic Material for Solution-Processed Organic/Si Hybrid Solar Cells with 17.5% Power Conversion Efficiency
by: Fahim Ullah, et al.
Published: (2024-11-01)

β-Hydroxy-β-methylbutyrate supplementation in a low protein diet: Implications on hemolymph parameters, immunity, endoplasmic reticulum stress and hepatopancreas histology of kuruma shrimp (Penaeus japonicus)
by: Hua Mu, et al.
Published: (2025-07-01)

Synthesis and biological evaluation of thieno[3,2-c]pyrazol-3-amine derivatives as potent glycogen synthase kinase 3β inhibitors for Alzheimer’s disease
by: Ning Yan, et al.
Published: (2022-12-01)

3-Chloropropiophenone
by: Marcel Sonneck, et al.
Published: (2025-04-01)

Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHB-HV) impregnated with mango leaves extracts using supercritical solvent impregnation
by: Ludisbel León-Marcos, et al.
Published: (2025-05-01)

Extraction of propionic acid by emulsion liquid membrane using trioctylamine in toluene
by: Aynur Manzak
Published: (2018-12-01)

PROPIONIC ACIDURIA IN A 5-MONTH-OLD CHILD
by: L. D. Fominykh, et al.
Published: (2014-01-01)

CHEMICAL EQUILIBRIUM IN THE PROPIONIC ACID - ETHANOL - ETHYL PROPIONATE - WATER SYSTEM AND EXTRACTION PROCESSES WITH PARTICIPATION OF DEEP EUTECTIC SOLVENTS
by: M. A. Toikka, et al.
Published: (2019-02-01)

Effect of Xenon on the Phosphorylation of Glycogen Synthase Kinase 3β and Antioxidant Enzymes in Rat Brain
by: A. N. Kuzovlev, et al.
Published: (2021-01-01)

SORBS3-β suppresses lymph node metastasis in cervical cancer by promoting the ubiquitination of β-catenin
by: Huating Sun, et al.
Published: (2025-04-01)

Gut microbiota-derived indole-3-propionic acid alleviates diabetic kidney disease through its mitochondrial protective effect via reducing ubiquitination mediated-degradation of SIRT1
by: Yan Zeng, et al.
Published: (2025-07-01)

SCFβ-TrCP targets Ajuba for degradation in a GSK3β-dependent manner in colorectal cancer
by: Liangshan Li, et al.
Published: (2025-08-01)

Carrot-Derived Rhamnogalacturonan-I Consistently Increases the Microbial Production of Health-Promoting Indole-3-Propionic Acid Ex Vivo
by: Annick Mercenier, et al.
Published: (2024-12-01)

Hyptolide induces ER stress-mediated cell death and enhances GSK3β-regulated cisplatin chemosensitivity in ovarian cancer
by: Yusi Luluk Rahmania, et al.
Published: (2025-06-01)