Inhibitory Effects of 3-(4-Hydroxy-3-methoxyphenyl) Propionic Acid on Amyloid β-Peptide Aggregation In Vitro

Inhibitory Effects of 3-(4-Hydroxy-3-methoxyphenyl) Propionic Acid on Amyloid β-Peptide Aggregation In Vitro

<b>Objectives</b>: The compound 3-(4-Hydroxy-3-methoxyphenyl) propionic acid (HMPA) is a terminal metabolite derived from polyphenol compounds. It has been studied for its potential to support brain health indirectly through its anti-oxidant effects and ability to enhance the gut environ...

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Bibliographic Details
Main Authors: Makoto Mori, Hiroto Nakano, Sadao Hikishima, Jota Minamikawa, Daiki Muramatsu, Yasuhiro Sakashita, Tokuhei Ikeda, Moeko Noguchi-Shinohara, Kenjiro Ono
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Biomedicines
Subjects:
3-(4-hydroxy-3-methoxyphenyl) propionic acid
amyloid β-protein
aggregation
nucleation
mature fibril Aβ seeds
Online Access:https://www.mdpi.com/2227-9059/13/7/1649
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