Sublytic Activity of a Pore‐Forming Protein From Commensal Bacteria Causes Epigenetic Modulation of Tumour‐Affiliated Protein Expression

Sublytic Activity of a Pore‐Forming Protein From Commensal Bacteria Causes Epigenetic Modulation of Tumour‐Affiliated Protein Expression

ABSTRACT Cytolysin A (ClyA) is a pore‐forming protein from a strongly silenced gene in non‐pathogenic Escherichia coli, including typical commensal isolates in the intestinal microbiome of healthy mammalian hosts. Upon overproduction, ClyA‐expressing bacteria display a cytolytic phenotype. However,...

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Main Authors: Eric Toh, Palwasha Baryalai, Aftab Nadeem, Kyaw Min Aung, Si Lhyam Myint, Nikola Zlatkov, Hadis Alidadi, Shaochun Zhu, André Mateus, Deepak Bushan Raina, Madeleine Ramstedt, Bernt Eric Uhlin, Sun Nyunt Wai
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Journal of Extracellular Vesicles
Subjects:
cancer cell epigenetics
non‐pathogenic Escherichia coli
outer membrane vesicles
pore‐forming protein cytolysin A
Online Access:https://doi.org/10.1002/jev2.70149
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https://doi.org/10.1002/jev2.70149

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