Role of CD28+ PD-1+ Tc cells in immune response and prognosis prediction in hepatocellular carcinoma

Role of CD28+ PD-1+ Tc cells in immune response and prognosis prediction in hepatocellular carcinoma

BackgroundCD28+PD-1+ Tc cells (CD8+ T cells) constitute a dysfunctional subset of T cell; however, the mechanisms underlying their dysfunction and their significance in hepatocellular carcinoma (HCC) remain unclear. We aimed to elucidate the prognostic significance and molecular characteristics of C...

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Bibliographic Details
Main Authors: Wuhan Yang, Teng Pan, Yaowen Chen, Hao Guo, Yaqi Peng, Chao Wang, Li Peng, Shubin Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
hepatocellular carcinoma
t cell exhaustion
CD28
PD-1
single-cell RNA-seq
tumor microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1576193/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1576193/full

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