Establishment of a prognostic model based on ER stress-related cell death genes and proposing a novel combination therapy in acute myeloid leukemia

Establishment of a prognostic model based on ER stress-related cell death genes and proposing a novel combination therapy in acute myeloid leukemia

Abstract Background Acute myeloid leukemia (AML) is a highly heterogeneous malignancy, presenting significant challenges in accurately predicting patient prognosis. Dysregulation of endoplasmic reticulum (ER) stress and resistance to programmed cell death (PCD) are hallmarks of AML cells. However, t...

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Main Authors: Minghui Wang, Huajian Xian, Xiaoli Xia, Wenjie Zhang, Zixuan Huang, Chaoqun Lu, Yuling Zheng, Yixin Wang, Shufeng Xie, Renyao Pan, YaoYifu Yu, Ruiheng Wang, Huijian Zheng, Guorui Huang, Han Liu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Translational Medicine
Subjects:
Acute myeloid leukemia
ER stress
Programmed cell death
Machine learning
DDIT4
Chaetocin
Online Access:https://doi.org/10.1186/s12967-025-06615-y
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https://doi.org/10.1186/s12967-025-06615-y

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