Computational screening identifies selective aldose reductase inhibitors with strong efficacy and limited off target interactions

Computational screening identifies selective aldose reductase inhibitors with strong efficacy and limited off target interactions

Abstract Diabetes mellitus is characterized by persistent hyperglycemia that triggers micro-vascular complications in organs such as the eyes and kidneys; a pivotal enzymatic driver is aldose reductase (AR), which reduces glucose to sorbitol. Because existing AR inhibitors often cause off-target tox...

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Bibliographic Details
Main Authors: Jicli Jose Rojas, Roberto Pestana-Nobles, Leonardo C. Pacheco-Londono, Jesús Utria-Munive, Nataly J. Galan-Freyle
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Diabetes mellitus
Aldose reductase
Docking
Molecular dynamics
Inhibitors
Antitarget proteins
Online Access:https://doi.org/10.1038/s41598-025-12859-x
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https://doi.org/10.1038/s41598-025-12859-x

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