Synergistic H&E and IHC image analysis by AI predicts cancer biomarkers and survival outcomes in colorectal and breast cancer

Synergistic H&E and IHC image analysis by AI predicts cancer biomarkers and survival outcomes in colorectal and breast cancer

Abstract Background Recent advancements in immunotherapy, particularly pembrolizumab, have shown promising results in treating metastatic colorectal cancer (CRC) and triple-negative breast cancer (TNBC). Accurate detection of predictive biomarkers, such as microsatellite instability (MSI)/mismatch r...

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Main Authors: Yating Cheng, Norsang Lama, Ming Chen, Eghbal Amidi, Mohammadreza Ramzanpour, Md Ashequr Rahman, Joanne Xiu, Anthony Helmstetter, Lauren Dickman, Jennifer R. Ribeiro, Hassan Ghani, Matthew Oberley, David Spetzler, George W. Sledge
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Communications Medicine
Online Access:https://doi.org/10.1038/s43856-025-01045-9
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https://doi.org/10.1038/s43856-025-01045-9

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