A novel technique for heart-thymus en bloc transplantation in nonhuman primates

A novel technique for heart-thymus en bloc transplantation in nonhuman primates

Abstract The thymus is a rich source of regulatory T cells and plays a role in self-tolerance. Therefore, transplantation of a vascularized donor thymus may facilitate the induction of tolerance in recipients of a cotransplanted heart allograft. To investigate this hypothesis, we developed a new tec...

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Bibliographic Details
Main Authors: James T. Nawalaniec, Samantha M. Landino, Jane M. O, Cynthia L. Miller, Abbas Dehnadi, Isabel Hanekamp, Jayne Marie Muoio, Casey Winter, Nicole Hays, James S. Allan, Joren C. Madsen
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Thymus transplant
Heart transplant
Regulatory T cells
Tolerance
Pediatric heart transplant
Online Access:https://doi.org/10.1038/s41598-024-83378-4
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https://doi.org/10.1038/s41598-024-83378-4

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