Hepatic-stellate-cell-targeted delivery of PU.1 decoy ODN by Apt-Tan attenuates liver fibrosis in mice

Hepatic-stellate-cell-targeted delivery of PU.1 decoy ODN by Apt-Tan attenuates liver fibrosis in mice

Targeted therapeutics for liver fibrosis (LF) are unavailable. PU.1 is a pioneer transcription factor (TF) that promotes hepatic stellate cell (HSC) activation and LF. PU.1 decoy oligodeoxynucleotides (ODNs) can potentially repress LF by capturing PU.1. In this study, we used Apt-Tan, a hepatic stel...

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Bibliographic Details
Main Authors: Yong Tan, Li-Ye Zhang, Yue Sun, Xiao-Jie Luo, Si-Yuan Wu, Xian-Zhi Wu, Yan-Qiong Zhang, Ying Wang, Bo-Tao Li, Yi-Ran Ni, Lan Ma, Jiang-Feng Wu
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides: Therapies and Applications
aptamer
SELEX
PU.1 decoy ODN
hepatic stellate cell
liver fibrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253125001611
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