Adhesin Als4112 promotes Candida auris skin colonization through interactions with keratinocytes and extracellular matrix proteins

Adhesin Als4112 promotes Candida auris skin colonization through interactions with keratinocytes and extracellular matrix proteins

Abstract Candida auris is a fungal pathogen notorious for persistent skin colonization and transmission in healthcare settings. Here, we show that a C. auris conserved adhesin, Als4112, is required for skin colonization via keratinocyte attachment and direct interactions with host extracellular matr...

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Main Authors: Guolei Zhao, Jingwen Lyu, Natalia A. Veniaminova, Robert Zarnowski, Eliciane Mattos, Chad J. Johnson, Derek Quintanilla, Haley Hautau, LeeAnn A. Hold, Bin Xu, Juliet A. E. Anku, Kaustav Dasgupta, Joseph J. Hale, Steph S. Steltzer, Darian J. Santana, Ashraf S. Ibrahim, Evan S. Snitkin, David Andes, Jeniel E. Nett, Shakti Singh, Adam C. Abraham, Megan L. Killian, J. Michelle Kahlenberg, Sunny Y. Wong, Teresa R. O’Meara
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60876-1
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https://doi.org/10.1038/s41467-025-60876-1

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