Higher levels of GluN1 splice cassettes, C2 and C2’, in hippocampus of aged mice were associated with poor spatial reference memory

Cognitive decline during aging has been linked to changes in the N-methyl-D-aspartate receptor (NMDAR). Age-related changes in the GluN1 splice cassette proteins have been described in crude synaptosomes, but synaptic and extrasynaptic NMDARs have different impacts on synaptic plasticity. The presen...

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Bibliographic Details
Main Authors: Kathy R. Magnusson, Daniel R. Zamzow
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Brain Research Bulletin
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923025003144
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