Dual nature of type I interferon responses and feedback regulations by SOCS1 dictate malaria mortality

Dual nature of type I interferon responses and feedback regulations by SOCS1 dictate malaria mortality

Introduction: Type I interferon (IFN-I, IFN-α/β), precisely controlled by multiple regulators, including suppressor of cytokine signaling 1 (SOCS1), is critical for host defense against pathogens. However, the impact of IFN-α/β on malaria parasite infections, beneficial or detrimental, remains contr...

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Bibliographic Details
Main Authors: Jiansen Lu, Zhiqiang Hu, Huaji Jiang, Zebin Wen, Hongyu Li, Jian Li, Ke Zeng, Yingchao Xie, Huadan Chen, Xin-zhuan Su, Chunmei Cai, Xiao Yu
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Journal of Advanced Research
Subjects:
Type I IFN
Plasmodium
SOCS1
scRNA-seq
Feedback regulation
Mathematical modeling
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123224003709
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