Heterologous expression, purification and characterization of Lactobacillus acidophilus CICC6074-derived slpX protein and the molecular mechanism of its anti-inflammatory effect on LPS-induced RAW264.7 cells

Heterologous expression, purification and characterization of Lactobacillus acidophilus CICC6074-derived slpX protein and the molecular mechanism of its anti-inflammatory effect on LPS-induced RAW264.7 cells

The role of S-layer proteins (SLP), which form the outermost layer of cell walls in lactic acid bacteria (LAB), plays a crucial role in regulating immune-stimulating activity, thereby closely influencing LAB’s ability to boost host immunity. In this study, the heterologous expression, purification,...

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Bibliographic Details
Main Authors: Yingying Cao, Xiankang Fan, Zihang Shi, Mingzhen Liu, Jue Xu, Tao Zhang, Xiaoqun Zeng, Zhen Wu, Daodong Pan
Format: Article
Language:English
Published: Tsinghua University Press 2025-05-01
Series:Food Science and Human Wellness
Subjects:
lactic acid bacteria
s-layer protein
inflammation
liquid chromatography-tandem mass spectrometry
enzyme-linked immunosorbnent assay
molecular docking
Online Access:https://www.sciopen.com/article/10.26599/FSHW.2024.9250230
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https://www.sciopen.com/article/10.26599/FSHW.2024.9250230

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