Peripheral Antinociception Induced by Carvacrol in the Formalin Test Involves the Opioid Receptor-NO-cGMP-K<sup>+</sup> Channel Pathway

Peripheral Antinociception Induced by Carvacrol in the Formalin Test Involves the Opioid Receptor-NO-cGMP-K<sup>+</sup> Channel Pathway

Background/Objectives: Carvacrol is a naturally occurring phenolic monoterpene that is one of the main constituents of the essential oils of oregano (<i>Origanum vulgare</i>) and other herbs. Carvacrol has anti-inflammatory and antinociceptive effects. Carvacrol can activate and inhibit...

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Bibliographic Details
Main Authors: Mario I. Ortiz, Raquel Cariño-Cortés, Eduardo Fernández-Martínez, Victor Manuel Muñoz-Pérez, Gilberto Castañeda-Hernández, Martha Patricia González-García
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Metabolites
Subjects:
carvacrol
antinociception
nitric oxide
cGMP
K<sup>+</sup> channels
Online Access:https://www.mdpi.com/2218-1989/15/5/314
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