Synergistic combination of valproic acid and oncolytic parvovirus H‐1PV as a potential therapy against cervical and pancreatic carcinomas

Synergistic combination of valproic acid and oncolytic parvovirus H‐1PV as a potential therapy against cervical and pancreatic carcinomas

Abstract The rat parvovirus H‐1PV has oncolytic and tumour‐suppressive properties potentially exploitable in cancer therapy. This possibility is being explored and results are encouraging, but it is necessary to improve the oncotoxicity of the virus. Here we show that this can be achieved by co‐trea...

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Main Authors: Junwei Li, Serena Bonifati, Georgi Hristov, Tiina Marttila, Séverine Valmary‐Degano, Sven Stanzel, Martina Schnölzer, Christiane Mougin, Marc Aprahamian, Svitlana P. Grekova, Zahari Raykov, Jean Rommelaere, Antonio Marchini
Format: Article
Language:English
Published: Springer Nature 2013-09-01
Series:EMBO Molecular Medicine
Subjects:
H‐1PV
pancreatic ductal adenocarcinomas
parvovirus NS1 protein
valproic acid
viral oncotherapy
Online Access:https://doi.org/10.1002/emmm.201302796
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https://doi.org/10.1002/emmm.201302796

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