Analytical and clinical validation of a NGS panel in detecting targetable variants from ctDNA of metastatic NSCLC patients

Analytical and clinical validation of a NGS panel in detecting targetable variants from ctDNA of metastatic NSCLC patients

Abstract Background Circulating tumor DNA (ctDNA) has emerged as a promising biomarker for noninvasive cancer diagnostics, particularly in the context of metastatic non‐small‐cell lung cancer (NSCLC). Detecting targetable variants through ctDNA analysis offers the potential to guide treatment decisi...

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Bibliographic Details
Main Authors: Feifei Fan, Guozhong Jiang, Juan Lv, Hongmin Wang, Wenjie Li, Chenglin Liu, Yu Zhao, Zhou Zhang, Haiwei Du, Zhihong Zhang, Xiangnan Li, Wen‐cai Li
Format: Article
Language:English
Published: Wiley 2024-10-01
Series:Cancer Medicine
Subjects:
circulating tumor DNA
concordance
next‐generation sequencing
targetable variants
tissue sample
Online Access:https://doi.org/10.1002/cam4.70078
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https://doi.org/10.1002/cam4.70078

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