IL-6R blockade combined with immunosuppressants alleviates adult-onset Still’s disease through immune remodeling: a mass cytometry study

IL-6R blockade combined with immunosuppressants alleviates adult-onset Still’s disease through immune remodeling: a mass cytometry study

Abstract Background Early administration of IL-6R blockade is effective in adult-onset Still’s disease (AOSD), but the underlying immune alterations during combined immunotherapy remain unclear. Methods We employed high-dimensional single-cell mass cytometry and an unbiased bioinformatics pipeline t...

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Bibliographic Details
Main Authors: Ruru Guo, Ting Zhang, Yixuan Li, Xuesong Liu, Xinyu Meng, Lei Tong, Xiaoxiang Chen, Xianting Ding, Liangjing Lu
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Translational Medicine
Subjects:
Adult-onset Still’s disease
Mass cytometry
Tocilizumab
Online Access:https://doi.org/10.1186/s12967-025-06597-x
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https://doi.org/10.1186/s12967-025-06597-x

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