Reduced Levels of Neurosteroids in Cerebrospinal Fluid of Amyotrophic Lateral Sclerosis Patients

Reduced Levels of Neurosteroids in Cerebrospinal Fluid of Amyotrophic Lateral Sclerosis Patients

Produced by the mitochondria and endoplasmic reticulum, neurosteroids such as allopregnanolone are neuroprotective molecules that influence various neuronal functions and regulate neuroinflammation. They are reduced in neurodegenerative diseases, while in the Wobbler mouse model, allopregnanolone an...

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Bibliographic Details
Main Authors: Chiara Lucchi, Cecilia Simonini, Cecilia Rustichelli, Rossella Avallone, Elisabetta Zucchi, Ilaria Martinelli, Giuseppe Biagini, Jessica Mandrioli
Format: Article
Language:English
Published: MDPI AG 2024-08-01
Series:Biomolecules
Subjects:
neurosteroids
amyotrophic lateral sclerosis
cerebrospinal fluid
Online Access:https://www.mdpi.com/2218-273X/14/9/1076
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