Effective therapeutic targeting of tumor lineage plasticity in neuroendocrine prostate cancer by BRD4 inhibitors

Effective therapeutic targeting of tumor lineage plasticity in neuroendocrine prostate cancer by BRD4 inhibitors

Tumor lineage plasticity (LP) is an emerging hallmark of cancer progression. Through pharmacologically probing the function of epigenetic regulators in prostate cancer cells and organoids, we identified bromodomain protein BRD4 as a crucial player. Integrated ChIP-seq and RNA-seq analysis of tumors...

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Bibliographic Details
Main Authors: Xiong Zhang, Yatian Yang, Hongye Zou, Yang Yang, Xingling Zheng, Eva Corey, Amina Zoubeidi, Nicolas Mitsiades, Ai-Ming Yu, Yuanpei Li, Hong-Wu Chen
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Tumor lineage plasticity
BRD4
Neurogenesis
AZD5153
FOXA1
ChIP-seq
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525000127
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