Risk of developing drug abuse in administration of a new hexaazaisowurtzitane derivative-based analgesic (experimental study)

Risk of developing drug abuse in administration of a new hexaazaisowurtzitane derivative-based analgesic (experimental study)

The aim of the study was to assess the probability of developing withdrawal syndrome caused by discontinuation of 5-day administration of thiowurtzine with naloxone challenge test in the experiment.Materials and methods. The test sample of the analgesic “Thiowurtzine, capsule 120 mg” served as the s...

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Bibliographic Details
Main Authors: S. G. Krylova, T. N. Pove’teva, K. A. Lopatina, Yu. V. Nesterova, E. P. Zueva, O. G. Afanas’eva, P. V. Kulpin, E. A. Kiseleva, N. I. Suslov, D. A. Kulagina, S. V. Sysolyatin, V. V. Zhdanov
Format: Article
Language:English
Published: Siberian State Medical University (Tomsk) 2022-04-01
Series:Бюллетень сибирской медицины
Subjects:
hexaazaisowurtzitane
thiowurtzine
analgesic activity
withdrawal syndrome
physical dependence
naloxone
tramadol
Online Access:https://bulletin.ssmu.ru/jour/article/view/4697
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https://bulletin.ssmu.ru/jour/article/view/4697

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