Citric Acid-Catalyzed Three-Component Synthesis of (<i>E</i>)-3-Aryl-2-styryl-2,3-dihydroquinazoline-4(1<i>H</i>)-ones and Their Mild Oxidation with I<sub>2</sub>/DMSO System into (<i>E</i>)-3-Aryl-2-styrylquinazolin-4(3<i>H</i>)-ones

Citric Acid-Catalyzed Three-Component Synthesis of (<i>E</i>)-3-Aryl-2-styryl-2,3-dihydroquinazoline-4(1<i>H</i>)-ones and Their Mild Oxidation with I<sub>2</sub>/DMSO System into (<i>E</i>)-3-Aryl-2-styrylquinazolin-4(3<i>H</i>)-ones

We hereby report a simple and efficient method for the preparation of (<i>E</i>)-3-aryl-2-styryl-2,3-dihydroquinazolin-4-(1<i>H</i>)-ones, from isatoic anhydride, anilines, and cinnamaldehydes in the presence of 20 mol% citric acid in methanol at 60 °C for 2 h. The styryl-dih...

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Bibliographic Details
Main Authors: Vladimir V. Kouznetsov, Angélica Peñaranda Gómez, Carlos E. Puerto Galvis
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Chemistry
Subjects:
three-component condensation reaction
2,3-dihydroquinazolin-4-(1<i>H</i>)-ones
quinazolin-4-(3<i>H</i>)-ones
styryl derivatives
organocatalysis
citric acid
Online Access:https://www.mdpi.com/2624-8549/7/2/42
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