Classification of collagen remodeling in asthma using second-harmonic generation imaging, supervised machine learning and texture-based analysis

Airway remodeling is present in all stages of asthma severity and has been linked to reduced lung function, airway hyperresponsiveness and increased deposition of fibrillar collagens. Traditional histological staining methods used to visualize the fibrotic response are poorly suited to capture the m...

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Bibliographic Details
Main Authors: Natasha N. Kunchur, Joshua J. A. Poole, Jesse Levine, Tillie-Louise Hackett, Rebecca Thornhill, Leila B. Mostaço-Guidolin
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Bioinformatics
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Online Access:https://www.frontiersin.org/articles/10.3389/fbinf.2025.1539936/full
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