An all-in-one pipeline for the in vitro discovery and in vivo testing of Plasmodium falciparum malaria transmission blocking drugs

An all-in-one pipeline for the in vitro discovery and in vivo testing of Plasmodium falciparum malaria transmission blocking drugs

Abstract Elimination of malaria will require new drugs with potent activity against Plasmodium falciparum mature stage V gametocytes, the only stages infective to the mosquito vector. The identification and comprehensive validation of molecules active against these quiescent stages is difficult due...

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Main Authors: Nicolas M. B. Brancucci, Christin Gumpp, Geert-Jan van Gemert, Xiao Yu, Armin Passecker, Flore Nardella, Basil T. Thommen, Marc Chambon, Gerardo Turcatti, Ludovic Halby, Benjamin Blasco, Maëlle Duffey, Paola B. Arimondo, Teun Bousema, Artur Scherf, Didier Leroy, Taco W. A. Kooij, Matthias Rottmann, Till S. Voss
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62014-3
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https://doi.org/10.1038/s41467-025-62014-3

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