The CRL7FBXW8 Complex Controls the Mammary Stem Cell Compartment through Regulation of NUMB Levels

The CRL7FBXW8 Complex Controls the Mammary Stem Cell Compartment through Regulation of NUMB Levels

Abstract NUMB is a tumor suppressor gene that functions by inhibiting the action of the NOTCH proto‐oncogene and enhancing the levels and activity of the tumor suppressor protein p53. In breast cancer (BC), NUMB loss of function (LOF), mediated by various molecular mechanisms, is a frequent and caus...

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Main Authors: Simone Sabbioni, Maria Grazia Filippone, Letizia Amadori, Stefano Confalonieri, Roberta Bonfanti, Stefano Capoano, Ivan Nicola Colaluca, Stefano Freddi, Giovanni Bertalot, Giovanni Fagà, Elisa Zagarrí, Mario Varasi, Rosalind Helen Gunby, Ciro Mercurio, Salvatore Pece, Pier Paolo Di Fiore, Daniela Tosoni
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Advanced Science
Subjects:
breast cancer
cancer stem cells
CRL7FBXW8 complex
NUMB
proteasomal degradation
Online Access:https://doi.org/10.1002/advs.202405812
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https://doi.org/10.1002/advs.202405812

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