Inhibition of insulin/IGF‐1 receptor signaling protects from mitochondria‐mediated kidney failure

Inhibition of insulin/IGF‐1 receptor signaling protects from mitochondria‐mediated kidney failure

Abstract Mitochondrial dysfunction and alterations in energy metabolism have been implicated in a variety of human diseases. Mitochondrial fusion is essential for maintenance of mitochondrial function and requires the prohibitin ring complex subunit prohibitin‐2 (PHB2) at the mitochondrial inner mem...

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Main Authors: Christina Ising, Sybille Koehler, Sebastian Brähler, Carsten Merkwirth, Martin Höhne, Olivier R Baris, Henning Hagmann, Martin Kann, Francesca Fabretti, Claudia Dafinger, Wilhelm Bloch, Bernhard Schermer, Andreas Linkermann, Jens C Brüning, Christine E Kurschat, Roman‐Ulrich Müller, Rudolf J Wiesner, Thomas Langer, Thomas Benzing, Paul Thomas Brinkkoetter
Format: Article
Language:English
Published: Springer Nature 2015-02-01
Series:EMBO Molecular Medicine
Subjects:
insulin
mitochondria
mTOR
podocyte
Online Access:https://doi.org/10.15252/emmm.201404916
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