Lobectomy sufficiency for 1–4 cm differential thyroid cancer: a large retrospective study in China
Abstract This study aimed to determine whether lobectomy is appropriate for the long-term prognosis of 1–4-cm-sized differential thyroid cancer (DTC). This retrospective study included 2,178 patients with 1–4-cm DTC treated via thyroid lobectomy (LT) or total or near-total thyroidectomy (TT) and who...
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2024-12-01
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| author | Jun Xu Qixian Yao Zhongliang Wu Wenhuan Dou Yujing Liu |
| author_facet | Jun Xu Qixian Yao Zhongliang Wu Wenhuan Dou Yujing Liu |
| author_sort | Jun Xu |
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| description | Abstract This study aimed to determine whether lobectomy is appropriate for the long-term prognosis of 1–4-cm-sized differential thyroid cancer (DTC). This retrospective study included 2,178 patients with 1–4-cm DTC treated via thyroid lobectomy (LT) or total or near-total thyroidectomy (TT) and who were followed up for at least 3 years. The primary endpoint was a structural incomplete response, which was confirmed via imaging with or without a positive histological or cytological examination. Subgroup analysis was performed according to tumor size. LT was performed in 1,535 patients (70.48%), and TT was conducted in the remaining 643 (29.55%) patients. During an average follow-up period of 48.08 months, the recurrence rate was 7.2% in the LT group and 5.3% in the TT group, which was not significantly different (p = 0.108). There were no significant differences in disease-free survival between both groups (hazard ratio, 1.394; 95% confidence interval, 0.9761–1.990; p = 0.089). In the subgroup analysis, the recurrence rates in the LT group were higher than those in the TT group for both the 2–3-cm (13.6% vs. 2.6%, p < 0.01) and 3–4-cm categories (20.6% vs. 4.8%, p < 0.01). For 1–2-cm DTC, surgeons can choose LT or TT owing to their similar recurrence rate, whereas for 2–4-cm DTC, TT is preferred. |
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| institution | Kabale University |
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| spelling | doaj-art-aae05944f5034bd88112d520aac01be12025-01-05T12:26:39ZengNature PortfolioScientific Reports2045-23222024-12-011411710.1038/s41598-024-83893-4Lobectomy sufficiency for 1–4 cm differential thyroid cancer: a large retrospective study in ChinaJun Xu0Qixian Yao1Zhongliang Wu2Wenhuan Dou3Yujing Liu4Department of Rehabilitation, The People’s Hospital of Suzhou New DistrictDepartment of Surgery, Community Health Service Center of Suzhou Science & Technology TownDepartment of General Surgery, The Second Affiliated Hospital of Soochow UniversityDepartment of Gastroenterology, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing UniversityDepartment of General Surgery II, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing UniversityAbstract This study aimed to determine whether lobectomy is appropriate for the long-term prognosis of 1–4-cm-sized differential thyroid cancer (DTC). This retrospective study included 2,178 patients with 1–4-cm DTC treated via thyroid lobectomy (LT) or total or near-total thyroidectomy (TT) and who were followed up for at least 3 years. The primary endpoint was a structural incomplete response, which was confirmed via imaging with or without a positive histological or cytological examination. Subgroup analysis was performed according to tumor size. LT was performed in 1,535 patients (70.48%), and TT was conducted in the remaining 643 (29.55%) patients. During an average follow-up period of 48.08 months, the recurrence rate was 7.2% in the LT group and 5.3% in the TT group, which was not significantly different (p = 0.108). There were no significant differences in disease-free survival between both groups (hazard ratio, 1.394; 95% confidence interval, 0.9761–1.990; p = 0.089). In the subgroup analysis, the recurrence rates in the LT group were higher than those in the TT group for both the 2–3-cm (13.6% vs. 2.6%, p < 0.01) and 3–4-cm categories (20.6% vs. 4.8%, p < 0.01). For 1–2-cm DTC, surgeons can choose LT or TT owing to their similar recurrence rate, whereas for 2–4-cm DTC, TT is preferred.https://doi.org/10.1038/s41598-024-83893-4Differentiated thyroid carcinomaRecurrenceLobectomyThyroidectomy |
| spellingShingle | Jun Xu Qixian Yao Zhongliang Wu Wenhuan Dou Yujing Liu Lobectomy sufficiency for 1–4 cm differential thyroid cancer: a large retrospective study in China Scientific Reports Differentiated thyroid carcinoma Recurrence Lobectomy Thyroidectomy |
| title | Lobectomy sufficiency for 1–4 cm differential thyroid cancer: a large retrospective study in China |
| title_full | Lobectomy sufficiency for 1–4 cm differential thyroid cancer: a large retrospective study in China |
| title_fullStr | Lobectomy sufficiency for 1–4 cm differential thyroid cancer: a large retrospective study in China |
| title_full_unstemmed | Lobectomy sufficiency for 1–4 cm differential thyroid cancer: a large retrospective study in China |
| title_short | Lobectomy sufficiency for 1–4 cm differential thyroid cancer: a large retrospective study in China |
| title_sort | lobectomy sufficiency for 1 4 cm differential thyroid cancer a large retrospective study in china |
| topic | Differentiated thyroid carcinoma Recurrence Lobectomy Thyroidectomy |
| url | https://doi.org/10.1038/s41598-024-83893-4 |
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