Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer

Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer

Abstract While dysregulation of polyamine metabolism is frequently observed in cancer, it is unknown how polyamines alter the tumor microenvironment (TME) and contribute to therapeutic resistance. Analysis of polyamines in the plasma of pancreatic cancer patients reveals that spermine levels are sig...

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Main Authors: Hanshen Yang, Xiaozhen Zhang, Sirui Zhang, Yanqing Yang, Yan Chen, Yangwei Jiang, Qingsong Lu, Lingyue Liu, Mengyi Lao, Weiran Du, Kang Sun, Lihong He, Jiatao Shi, Xinyuan Liu, Jinyuan Song, Na Lu, Junming Huang, Jinyan Huang, Ruhong Zhou, Xiongbin Lu, Tingbo Liang, Xueli Bai
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-63146-2
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https://doi.org/10.1038/s41467-025-63146-2

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