Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

ABSTRACT Celastrol (CEL) is a natural pentacyclic triterpenoid demonstrating significant therapeutic properties against various diseases. However, the ambiguity of target information poses a significant challenge in transitioning CEL from a traditional remedy to a modern pharmaceutical agent. Recent...

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Bibliographic Details
Main Authors: Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Exploration
Subjects:
celastrol
combination therapy
drug delivery
natural product
target identification
target validation
Online Access:https://doi.org/10.1002/EXP.20240247
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https://doi.org/10.1002/EXP.20240247

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