Hepatotoxicity evaluation of cannabidiol, cannabinol, cannabichromene and cannabigerol using a human quad culture liver chip

Abstract Due to the increasing availability of hemp-derived products for recreational and medicinal use, it is imperative to understand the hepatotoxicity of the naturally occurring phytocannabinoids. Though, traditionally animal models or in vitro techniques are used to evaluate hepatotoxicity, the...

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Bibliographic Details
Main Authors: Jacob D. Larson, Sushma Jadalannagari, Jake Chaff, James Velez, Josiah Sliz, Lorna Ewart, Donna Webster, Jiang Hu
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-12846-2
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