Enhanced potency of immune checkpoint inhibitors against poorly immunological solid tumors by immune stimulatory oncolytic adenoviruses-mediated remodeling of the tumor microenvironment

Enhanced potency of immune checkpoint inhibitors against poorly immunological solid tumors by immune stimulatory oncolytic adenoviruses-mediated remodeling of the tumor microenvironment

Abstract Immune checkpoint inhibitor (ICI) have shown promising results against a variety of solid tumors across clinical trials. However, ICI monotherapy is often ineffective in patients with non-immunogenic tumors that exhibit high level of immunosuppression and low level of tumor infiltrating lym...

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Bibliographic Details
Main Authors: Hyo Min Ahn, Bo-Kyeong Jung, JinWoo Hong, Dayoung Hong, A-Rum Yoon, Chae-Ok Yun
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Medicine
Subjects:
Checkpoint inhibitors
Oncolytic adenovirus
Programmed cell death protein 1
Programmed death-ligand 1
Cytotoxic T lymphocyte-associated protein 4
Combination therapy
Online Access:https://doi.org/10.1186/s10020-025-01223-4
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https://doi.org/10.1186/s10020-025-01223-4

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