High-content Image-based Drug Testing of Patients’ Primary Fibroblasts Reveals Potential New Treatment Options for Localized Scleroderma

High-content Image-based Drug Testing of Patients’ Primary Fibroblasts Reveals Potential New Treatment Options for Localized Scleroderma

Localized scleroderma is a rare autoimmune disease characterized by progressive fibrosis of the skin and its underlying structures, causing loss of normal tissue structure and function. Myofibroblasts, differentiated from fibroblasts by high expression of α-smooth muscle actin, play a key role in th...

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Bibliographic Details
Main Authors: Katariina Mähönen, Isabel Mogollon, Antti Hassinen, Minttu Polso, Katja Välimäki, Swapnil Potdar, Al-Amin Chowdhury, Annamari Ranki, Jani Saarela, Vilja Pietiäinen, Jaana Panelius
Format: Article
Language:English
Published: Medical Journals Sweden 2025-08-01
Series:Acta Dermato-Venereologica
Subjects:
Localized scleroderma
Myofibroblasts
transforming growth factor beta
antifibrotic agents
high throughput screening assay
Online Access:https://medicaljournalssweden.se/actadv/article/view/43088
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