Cisplatin and Alternating Temozolomide in Recurrent High-Grade Gliomas: Efficacy and the Role of Tumor-Infiltrating Lymphocytes in a Phase II Clinical Trial

Background: To evaluate the efficacy and safety of cisplatin combined with alternating temozolomide (TMZ) for recurrent high-grade glioma, as current treatments lack standardized protocols and predictive markers. Methods: This study evaluated cisplatin (20 mg/m 2 IV, days 1-3) and TMZ (125 mg/m 2 or...

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Main Authors: Xiaojie Ding, Di Chen, Zhenyu Zhang, Ying Qi, Dikang Chen, Jianbo Wen, Yuyuan Wang, Haixia Cheng, Chunxia Ji, Lingchao Chen, Chao Tang, Yu Yao
Format: Article
Language:English
Published: SAGE Publishing 2025-07-01
Series:Clinical Medicine Insights: Oncology
Online Access:https://doi.org/10.1177/11795549251350188
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