4-1BBL-Armed Oncolytic Herpes Simplex Virus Exerts Antitumor Effects in Pancreatic Ductal Adenocarcinoma

4-1BBL-Armed Oncolytic Herpes Simplex Virus Exerts Antitumor Effects in Pancreatic Ductal Adenocarcinoma

<b>Background:</b> Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with a notably poor response to therapy due to its immunosuppressive tumor microenvironment (TME) and intrinsic drug resistance. The oncolytic virus (OV) represents a promising therapeutic strategy cap...

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Bibliographic Details
Main Authors: Wenrui Gao, Zhuoqian Zhao, Ying Bi, Jinghua Li, Na Tian, Cuizhu Zhang, Shuyuan Pan, Li Deng, Yuntao Zhang
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Vaccines
Subjects:
PDAC
oncolytic virus
herpes simplex virus
4-1BBL
PD-1
Online Access:https://www.mdpi.com/2076-393X/12/12/1309
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