The hydroxamate based HDAC inhibitor WMJ-J-09 induces colorectal cancer cell death by targeting tubulin and downregulating survivin

The hydroxamate based HDAC inhibitor WMJ-J-09 induces colorectal cancer cell death by targeting tubulin and downregulating survivin

Abstract Aberrant expression of histone deacetylases (HDACs) is associated with cancer drug resistance and tumor progression. While considerable studies and effort have been devoted to developing novel HDAC inhibitors in cancer therapy, hydroxamate-based HDAC inhibitors have gained growing interest...

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Main Authors: Yu-Han Huang, Yu-Min Huang, Wei-Jan Huang, Meng-Chieh Yu, Chin-Hui Chuang, Ya-Fen Hsu, Hsiu-Chen Chen, Liang-Chieh Chen, Shiu-Wen Huang, Ming-Jen Hsu
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Acetylation
Histone deacetylase (HDAC)
Liver kinase B1 (LKB1)
P53
Survivin
Online Access:https://doi.org/10.1038/s41598-025-04714-w
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https://doi.org/10.1038/s41598-025-04714-w

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