SIRPα modulates microglial efferocytosis and neuroinflammation following experimental subarachnoid hemorrhage via the SHP1/STAT6 axis

SIRPα modulates microglial efferocytosis and neuroinflammation following experimental subarachnoid hemorrhage via the SHP1/STAT6 axis

Abstract Subarachnoid hemorrhage induces extensive neuronal cell death, leading to the release of damage-associated molecular patterns (DAMPs). These DAMPs, along with hemoglobin and cell corpses, trigger localized inflammation. Signal regulatory protein alpha (SIRPα) plays a crucial role in efferoc...

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Bibliographic Details
Main Authors: Bingtao Zhang, Yan Zou, Qikai Tang, Zixuan Yuan, Kun Jiang, Zhaoxiang Zhang, Shujuan Chen, Qi Wu, Xiaoming Zhou, Xin Zhang
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Neuroinflammation
Subjects:
Subarachnoid hemorrhage
Neuroinflammation
Efferocytosis
Signal regulatory protein alpha
Signal transducer and activator of transcription 6
Online Access:https://doi.org/10.1186/s12974-025-03414-6
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https://doi.org/10.1186/s12974-025-03414-6

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