Curcumin Modulates PTPRZ1 Activity and RNA m6A Modifications in Neuroinflammation‐Associated Microglial Response
Abstract Neuroinflammation is often characterized by an overactive microglial response. Curcumin, known for its anti‐inflammatory and antioxidant properties, can mitigate microglial hyperactivity following epileptic seizures. The study delves into the molecular mechanisms underlying curcumin's...
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| Format: | Article |
| Language: | English |
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Wiley
2025-04-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202405263 |
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| author | Ninan Zhang Ruifan Lin Wenya Gao Honglin Xu Yuejia Li Xiahe Huang Yingchun Wang Xianghong Jing Wenxiang Meng Qi Xie |
| author_facet | Ninan Zhang Ruifan Lin Wenya Gao Honglin Xu Yuejia Li Xiahe Huang Yingchun Wang Xianghong Jing Wenxiang Meng Qi Xie |
| author_sort | Ninan Zhang |
| collection | DOAJ |
| description | Abstract Neuroinflammation is often characterized by an overactive microglial response. Curcumin, known for its anti‐inflammatory and antioxidant properties, can mitigate microglial hyperactivity following epileptic seizures. The study delves into the molecular mechanisms underlying curcumin's modulation of RNA post‐transcriptional N (6)‐methyladenosine (m6A) modification. It is found that curcumin interacts with the Z1‐type protein tyrosine phosphatase receptor (PTPRZ1), maintaining its enzymatic activity and thus regulating the phosphorylation of the m6A‐reader YTH domain‐containing family protein 2 (YTHDF2). This modulation affects the expression of critical genes, resulting in reduced inflammatory responses. These findings highlight the importance of post‐transcriptional modifications of RNA in the neuroprotective and anti‐inflammatory effects of curcumin, offering new insights for the treatment of related diseases. |
| format | Article |
| id | doaj-art-aa921dd717f6423985bb8dce01c56936 |
| institution | DOAJ |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-aa921dd717f6423985bb8dce01c569362025-08-20T03:18:05ZengWileyAdvanced Science2198-38442025-04-011215n/an/a10.1002/advs.202405263Curcumin Modulates PTPRZ1 Activity and RNA m6A Modifications in Neuroinflammation‐Associated Microglial ResponseNinan Zhang0Ruifan Lin1Wenya Gao2Honglin Xu3Yuejia Li4Xiahe Huang5Yingchun Wang6Xianghong Jing7Wenxiang Meng8Qi Xie9Institute of Acupuncture and Moxibustion China Academy of Chinese Medical Sciences Beijing 100700 ChinaInstitute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences Beijing 100700 ChinaInstitute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences Beijing 100700 ChinaState Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 10019 ChinaState Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 10019 ChinaState Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 10019 ChinaState Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 10019 ChinaInstitute of Acupuncture and Moxibustion China Academy of Chinese Medical Sciences Beijing 100700 ChinaState Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 10019 ChinaWangjing Hospital of China Academy of Chinese Medical Sciences Beijing 100102 ChinaAbstract Neuroinflammation is often characterized by an overactive microglial response. Curcumin, known for its anti‐inflammatory and antioxidant properties, can mitigate microglial hyperactivity following epileptic seizures. The study delves into the molecular mechanisms underlying curcumin's modulation of RNA post‐transcriptional N (6)‐methyladenosine (m6A) modification. It is found that curcumin interacts with the Z1‐type protein tyrosine phosphatase receptor (PTPRZ1), maintaining its enzymatic activity and thus regulating the phosphorylation of the m6A‐reader YTH domain‐containing family protein 2 (YTHDF2). This modulation affects the expression of critical genes, resulting in reduced inflammatory responses. These findings highlight the importance of post‐transcriptional modifications of RNA in the neuroprotective and anti‐inflammatory effects of curcumin, offering new insights for the treatment of related diseases.https://doi.org/10.1002/advs.202405263anti‐inflammatorycurcuminm6A post‐transcriptional modifications of RNAmicroglia homeostasisPTPRZ1 |
| spellingShingle | Ninan Zhang Ruifan Lin Wenya Gao Honglin Xu Yuejia Li Xiahe Huang Yingchun Wang Xianghong Jing Wenxiang Meng Qi Xie Curcumin Modulates PTPRZ1 Activity and RNA m6A Modifications in Neuroinflammation‐Associated Microglial Response Advanced Science anti‐inflammatory curcumin m6A post‐transcriptional modifications of RNA microglia homeostasis PTPRZ1 |
| title | Curcumin Modulates PTPRZ1 Activity and RNA m6A Modifications in Neuroinflammation‐Associated Microglial Response |
| title_full | Curcumin Modulates PTPRZ1 Activity and RNA m6A Modifications in Neuroinflammation‐Associated Microglial Response |
| title_fullStr | Curcumin Modulates PTPRZ1 Activity and RNA m6A Modifications in Neuroinflammation‐Associated Microglial Response |
| title_full_unstemmed | Curcumin Modulates PTPRZ1 Activity and RNA m6A Modifications in Neuroinflammation‐Associated Microglial Response |
| title_short | Curcumin Modulates PTPRZ1 Activity and RNA m6A Modifications in Neuroinflammation‐Associated Microglial Response |
| title_sort | curcumin modulates ptprz1 activity and rna m6a modifications in neuroinflammation associated microglial response |
| topic | anti‐inflammatory curcumin m6A post‐transcriptional modifications of RNA microglia homeostasis PTPRZ1 |
| url | https://doi.org/10.1002/advs.202405263 |
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