FBXO10 Drives Hepatocellular Carcinoma Proliferation via K63-Linked Ubiquitination and Stabilization of FRMPD1

FBXO10 Drives Hepatocellular Carcinoma Proliferation via K63-Linked Ubiquitination and Stabilization of FRMPD1

Aberrant ubiquitination drives hepatocellular carcinoma (HCC) progression, yet the role of FBXO10—a key F-box E3 ubiquitin ligase component—remains uncharacterized. Through bioinformatics analyses and functional validation, we establish FBXO10 as a critical oncogenic driver in HCC. Transcriptomic da...

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Bibliographic Details
Main Authors: Wuguang Liu, Bin Xu, Kashif Kifayat, Yuhong Xie, Xiaolong Liu, Chengyong Dong, Liming Wang
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Current Issues in Molecular Biology
Subjects:
hepatocarcinoma
FBXO10
FRMPD1
ubiquitination
cell proliferation
Online Access:https://www.mdpi.com/1467-3045/47/6/391
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