Target Mapping in Cancer: Ligandable Protein Pockets on 3D OncoPPI Networks

Target Mapping in Cancer: Ligandable Protein Pockets on 3D OncoPPI Networks

<b>Background/Objectives:</b> Studying protein–protein interaction (PPI) networks is crucial in understanding cancer phenotypes and molecular mechanisms. Here, we focus on PPIs involved in 12 different types of cancer (oncoPPIs), highlighting those protein pockets serving as outposts to...

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Bibliographic Details
Main Authors: Daniela Trisciuzzi, Orazio Nicolotti, Gabriele Cruciani, Gabriele Menna, Lydia Siragusa
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Pharmaceuticals
Subjects:
ligandable pockets
3D oncoPPI networks
PPIs modulators
PROTACs
pocketome analysis
target prioritization in cancer
Online Access:https://www.mdpi.com/1424-8247/18/7/958
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