Targeting MMP-9 activation after early-life seizures reduces seizure susceptibility and memory deficits in a larval zebrafish model

Targeting MMP-9 activation after early-life seizures reduces seizure susceptibility and memory deficits in a larval zebrafish model

One in 26 Americans experience seizures, with a high incidence occurring in the first years of life. Chronic consequences of prolonged early-life seizures (ELS) in humans and rodent models vary, but can include the development of epilepsy (spontaneous, recurrent seizures) and cognitive impairment. B...

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Bibliographic Details
Main Authors: Christopher Stegmuller, Alfonsina Ramón, Kasulul Melissa Bhuiyan, Nat Berk, Rebecca Han, Faisha Salami, Marina D'Angelo, Jocelyn J. Lippman-Bell
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Neurobiology of Disease
Subjects:
Animal seizure models
Neurodevelopment
Pharmacological intervention
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125001949
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