Evaluating pediatric tuberculosis dosing guidelines: A model-based individual data pooled analysis.

Evaluating pediatric tuberculosis dosing guidelines: A model-based individual data pooled analysis.

<h4>Background</h4>The current World Health Organization (WHO) pediatric tuberculosis dosing guidelines lead to suboptimal drug exposures. Identifying factors altering the exposure of these drugs in children is essential for dose optimization. Pediatric pharmacokinetic studies are usuall...

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Main Authors: Lufina Tsirizani Galileya, Roeland E Wasmann, Chishala Chabala, Helena Rabie, Janice Lee, Irene Njahira Mukui, Anneke Hesseling, Heather Zar, Rob Aarnoutse, Anna Turkova, Diana Gibb, Mark F Cotton, Helen McIlleron, Paolo Denti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-11-01
Series:PLoS Medicine
Online Access:https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1004303&type=printable
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https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1004303&type=printable

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