Lactate dehydrogenase is the Achilles’ heel of Lyme disease bacterium Borreliella burgdorferi

Lactate dehydrogenase is the Achilles’ heel of Lyme disease bacterium Borreliella burgdorferi

ABSTRACT As a zoonotic pathogen, the Lyme disease bacterium Borreliella burgdorferi has evolved unique metabolic pathways, some of which are specific and essential for its survival and thus present as ideal targets for developing new therapeutics. B. burgdorferi dispenses with the use of thiamin as...

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Bibliographic Details
Main Authors: Ching Wooen Sze, Michael J. Lynch, Kai Zhang, David B. Neau, Steven E. Ealick, Brian R. Crane, Chunhao Li
Format: Article
Language:English
Published: American Society for Microbiology 2025-04-01
Series:mBio
Subjects:
Lyme disease
Borrelia burgdorferi
lactate dehydrogenase
antibiotics
drug screening
Online Access:https://journals.asm.org/doi/10.1128/mbio.03728-24
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https://journals.asm.org/doi/10.1128/mbio.03728-24

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