Association between Visceral Fat and Bone Mineral Density in Both Male and Female Patients with Adult Growth Hormone Deficiency
Aim. Adult growth hormone deficiency (AGHD) is associated with an increased risk of fractures. The interactions between various body composition and bone are known to be complex in nature. However, very few studies have examined this crosstalk in AGHD. In this study, we sought to investigate the rel...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2020/5079625 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832546965381971968 |
|---|---|
| author | Linman Li Li Zhong Xiaoya Zheng Wenyi You Yunting Wang Jihui Yu Xun Wu Wei Ren Gangyi Yang |
| author_facet | Linman Li Li Zhong Xiaoya Zheng Wenyi You Yunting Wang Jihui Yu Xun Wu Wei Ren Gangyi Yang |
| author_sort | Linman Li |
| collection | DOAJ |
| description | Aim. Adult growth hormone deficiency (AGHD) is associated with an increased risk of fractures. The interactions between various body composition and bone are known to be complex in nature. However, very few studies have examined this crosstalk in AGHD. In this study, we sought to investigate the relationship between various parameters of body composition and bone mineral density (BMD) as well as determine the role of visceral fat in determining the bone mass in patients with AGHD. Methods. We conducted a cross-sectional study on 57 patients with AGHD. Anthropometry, biochemistry, and analysis of body composition and BMD were performed according to standard protocols. Male and female patients were classified into those with osteoporosis and those without osteoporosis (normal subjects and patients with osteopenia). Further, we analyzed the correlation between the BMD and measurements obtained for various body composition parameters in male and female AGHD patients. Results. Our findings indicated that among female AGHD patients, those with osteoporosis had a significantly higher levels of fat mass (FM) and visceral adipose tissue mass (VATM) (both, P<0.05) than those without osteoporosis. Further, Pearson correlation analysis showed that the values of age, body mass index (BMI), FM, and VATM correlated negatively with BMD in women with AGHD (all P<0.05); however, this association was not noted in men. After adjusting for the other covariates, VATM was found to be independently correlated with the BMD in female patients with AGHD. Conclusions. A close correlation was noted between VATM and BMD in female patients with AGHD. |
| format | Article |
| id | doaj-art-aa6077d4493f42978561f45e670c57df |
| institution | Kabale University |
| issn | 2090-2247 2090-2255 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Biochemistry Research International |
| spelling | doaj-art-aa6077d4493f42978561f45e670c57df2025-02-03T06:46:35ZengWileyBiochemistry Research International2090-22472090-22552020-01-01202010.1155/2020/50796255079625Association between Visceral Fat and Bone Mineral Density in Both Male and Female Patients with Adult Growth Hormone DeficiencyLinman Li0Li Zhong1Xiaoya Zheng2Wenyi You3Yunting Wang4Jihui Yu5Xun Wu6Wei Ren7Gangyi Yang8Department of Health Management Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaDepartment of Health Management Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaInfectious Diseases Department, The People’s Hospital of Yubei District of Chongqing City, Chongqing 401120, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaDepartment of Health Management Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaDepartment of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, ChinaAim. Adult growth hormone deficiency (AGHD) is associated with an increased risk of fractures. The interactions between various body composition and bone are known to be complex in nature. However, very few studies have examined this crosstalk in AGHD. In this study, we sought to investigate the relationship between various parameters of body composition and bone mineral density (BMD) as well as determine the role of visceral fat in determining the bone mass in patients with AGHD. Methods. We conducted a cross-sectional study on 57 patients with AGHD. Anthropometry, biochemistry, and analysis of body composition and BMD were performed according to standard protocols. Male and female patients were classified into those with osteoporosis and those without osteoporosis (normal subjects and patients with osteopenia). Further, we analyzed the correlation between the BMD and measurements obtained for various body composition parameters in male and female AGHD patients. Results. Our findings indicated that among female AGHD patients, those with osteoporosis had a significantly higher levels of fat mass (FM) and visceral adipose tissue mass (VATM) (both, P<0.05) than those without osteoporosis. Further, Pearson correlation analysis showed that the values of age, body mass index (BMI), FM, and VATM correlated negatively with BMD in women with AGHD (all P<0.05); however, this association was not noted in men. After adjusting for the other covariates, VATM was found to be independently correlated with the BMD in female patients with AGHD. Conclusions. A close correlation was noted between VATM and BMD in female patients with AGHD.http://dx.doi.org/10.1155/2020/5079625 |
| spellingShingle | Linman Li Li Zhong Xiaoya Zheng Wenyi You Yunting Wang Jihui Yu Xun Wu Wei Ren Gangyi Yang Association between Visceral Fat and Bone Mineral Density in Both Male and Female Patients with Adult Growth Hormone Deficiency Biochemistry Research International |
| title | Association between Visceral Fat and Bone Mineral Density in Both Male and Female Patients with Adult Growth Hormone Deficiency |
| title_full | Association between Visceral Fat and Bone Mineral Density in Both Male and Female Patients with Adult Growth Hormone Deficiency |
| title_fullStr | Association between Visceral Fat and Bone Mineral Density in Both Male and Female Patients with Adult Growth Hormone Deficiency |
| title_full_unstemmed | Association between Visceral Fat and Bone Mineral Density in Both Male and Female Patients with Adult Growth Hormone Deficiency |
| title_short | Association between Visceral Fat and Bone Mineral Density in Both Male and Female Patients with Adult Growth Hormone Deficiency |
| title_sort | association between visceral fat and bone mineral density in both male and female patients with adult growth hormone deficiency |
| url | http://dx.doi.org/10.1155/2020/5079625 |
| work_keys_str_mv | AT linmanli associationbetweenvisceralfatandbonemineraldensityinbothmaleandfemalepatientswithadultgrowthhormonedeficiency AT lizhong associationbetweenvisceralfatandbonemineraldensityinbothmaleandfemalepatientswithadultgrowthhormonedeficiency AT xiaoyazheng associationbetweenvisceralfatandbonemineraldensityinbothmaleandfemalepatientswithadultgrowthhormonedeficiency AT wenyiyou associationbetweenvisceralfatandbonemineraldensityinbothmaleandfemalepatientswithadultgrowthhormonedeficiency AT yuntingwang associationbetweenvisceralfatandbonemineraldensityinbothmaleandfemalepatientswithadultgrowthhormonedeficiency AT jihuiyu associationbetweenvisceralfatandbonemineraldensityinbothmaleandfemalepatientswithadultgrowthhormonedeficiency AT xunwu associationbetweenvisceralfatandbonemineraldensityinbothmaleandfemalepatientswithadultgrowthhormonedeficiency AT weiren associationbetweenvisceralfatandbonemineraldensityinbothmaleandfemalepatientswithadultgrowthhormonedeficiency AT gangyiyang associationbetweenvisceralfatandbonemineraldensityinbothmaleandfemalepatientswithadultgrowthhormonedeficiency |