Halogenated 2,4-diphenyl indeno[1,2-B]pyridinol derivatives as potential inhibitors of the androgen receptor (PDB ID: 58TE): A study of QSAR modeling, molecular docking, and pharmacokinetics for prostate cancer treatment

Halogenated 2,4-diphenyl indeno[1,2-B]pyridinol derivatives as potential inhibitors of the androgen receptor (PDB ID: 58TE): A study of QSAR modeling, molecular docking, and pharmacokinetics for prostate cancer treatment

The present research was centered on the development of a predictive model aimed at assessing the responses of prostate tumors to a range of compounds within the scope of the pIC50 project. Our approach involved the utilization of a quantitative structure-activity relationship (QSAR) methodology, in...

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Bibliographic Details
Main Authors: Auwal Salisu Isa, Adamu Uzairu, Umar Mele Umar, Muhammad Tukur Ibrahim, David Ebuka Arthur, Samuel Ndaghiya Adawara
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-09-01
Series:Biomedical Analysis
Subjects:
QSAR
Docking Analysis
ADMET
Prostate cancer
DUA145
Online Access:http://www.sciencedirect.com/science/article/pii/S2950435X24000301
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