PLD1 is a key player in cancer stemness and chemoresistance: Therapeutic targeting of cross-talk between the PI3K/Akt and Wnt/β-catenin pathways

Abstract The development of chemoresistance is a major challenge in the treatment of several types of cancers in clinical settings. Stemness and chemoresistance are the chief causes of poor clinical outcomes. In this context, we hypothesized that understanding the signaling pathways responsible for...

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Bibliographic Details
Main Authors: Seong Hun Lim, Hyesung Lee, Hyun Ji Lee, Kuglae Kim, Junjeong Choi, Jung Min Han, Do Sik Min
Format: Article
Language:English
Published: Nature Publishing Group 2024-07-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-024-01260-9
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