NKG2D-CAR-targeted iPSC-derived MSCs efficiently target solid tumors expressing NKG2D ligand

NKG2D-CAR-targeted iPSC-derived MSCs efficiently target solid tumors expressing NKG2D ligand

Summary: Mesenchymal stem cells (MSCs) hold potential in cancer therapy; however, insufficient tumor homing ability and heterogeneity limit their therapeutic benefits. Obviously, the homogeneous induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells (iMSCs) with enhanced ability of tumo...

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Bibliographic Details
Main Authors: Shuqing Tang, Yusang Zhang, Peiyun Wang, Qiyu Tang, Yating Liu, Fan Lu, Mengting Han, Miaojin Zhou, Qian Hu, Mai Feng, Desheng Liang
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:iScience
Subjects:
Natural sciences
Biological sciences
Molecular biology
Cell biology
Systems biology
Cancer systems biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225006042
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http://www.sciencedirect.com/science/article/pii/S2589004225006042

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