Modeling drug retention as memory effects in obese patients using fractional and augmented models

Modeling drug retention as memory effects in obese patients using fractional and augmented models

Abstract Lipophilic anesthetic drugs accumulate in adipose tissue, leading to delayed release and prolonged effects, particularly in obese patients. This study proposes two novel physiologically motivated pharmacokinetic (PK) models to address these dynamics. The first is an augmented model with a t...

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Main Authors: Amani R. Ynineb, Erhan Yumuk, Dana Copot, Bora Ayvaz, Bouchra Khoumeri, Ghada Ben Othman, Marcian D. Mihai, Isabela R. Birs, Cristina I. Muresan, Clara M. Ionescu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Fractional calculus
Pharmacokinetics
Compartmental models
Memory effect
Caputo derivative
Online Access:https://doi.org/10.1038/s41598-025-10172-1
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https://doi.org/10.1038/s41598-025-10172-1

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